Altered open field behavior in rats induced by acute administration of 3-nitropropionic acid: possible glutamatergic and dopaminergic involvement.
Acta Biol Hung
; 60(4): 359-67, 2009 Dec.
Article
en En
| MEDLINE
| ID: mdl-20015828
ABSTRACT
3-nitropropionic acid (3-NP), a substance used for modelling Huntington's disease, was given to male Wistar rats in a single 20 mg/kg b.w. dose, and the resulting behavioral alterations in spontaneous locomotor activity were measured after 30 minutes. To detect the involvement of neurotransmitter systems in this immediate effect, the NMDA antagonist MK-801 (0.8 mg/kg); as well as an agonist, quinpirole (QP, 5 mg/kg) and an antagonist, sulpiride (SP, 80 mg/kg) of the dopamine D2 receptors, were given before 3-NP to separate groups of rats. Controls were given saline. All substances were injected ip. 3-NP decreased the rats' locomotor, especially vertical, activity, whereas local activity was increased. Based on the further changes of 3-NP effects in the combination groups it could be concluded that dopaminergic rather than glutamatergic mechanisms were possibly involved in the acute behavioral effect of 3-NP.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Propionatos
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Conducta Animal
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Receptores Dopaminérgicos
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Receptores de Glutamato
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Actividad Motora
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Nitrocompuestos
Límite:
Animals
Idioma:
En
Año:
2009
Tipo del documento:
Article