Synthesis and analysis of 2-[211At]-L-phenylalanine and 4-[211At]-L-phenylalanine and their uptake in human glioma cell cultures in-vitro.
Appl Radiat Isot
; 68(6): 1060-5, 2010 Jun.
Article
en En
| MEDLINE
| ID: mdl-20137958
ABSTRACT
2-[211At]-L-phenylalanine and 4-[211At]-L-phenylalanine were prepared from the corresponding iodo and bromo derivatives using the Cu(+)-assisted nucleophilic exchange. 4-[211At]-L-phenylalanine was additionally prepared by destannylation of the BOC-derivatized 4-tributylstannyl-L-phenylalanine. Radiochemical yields of 2-[211At]-L-phenylalanine and 4-[211At]-L-phenylalanine by nucleophilic exchange were 52-74% and 65-85%. Radiochemical yield of 4-[211At]-L-phenylalanine by electrophilic destannylation was 35-50%. HPLC sequence analysis showed that 2-[211At]-L-phenylalanine followed the halogen sequence (F
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fenilalanina
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Neoplasias Encefálicas
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Astato
/
Radiofármacos
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Glioma
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Marcaje Isotópico
Límite:
Humans
Idioma:
En
Año:
2010
Tipo del documento:
Article