Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.
Bioorg Med Chem Lett
; 20(7): 2264-9, 2010 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-20188554
ABSTRACT
Modifying FTY720, an immunosuppressant modulator, led to a new series of well phosphorylated tetralin analogs as potent S1P1 receptor agonists. The stereochemistry effect of tetralin ring was probed, and (-)-(R)-2-amino-2-((S)-6-octyl-1,2,3,4-tetrahydronaphthalen-2-yl)propan-1-ol was identified as a good SphK2 substrate and potent S1P1 agonist with good oral bioavailability.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tetrahidronaftalenos
/
Profármacos
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Receptores de Lisoesfingolípidos
/
Inmunosupresores
Límite:
Animals
Idioma:
En
Año:
2010
Tipo del documento:
Article