Design, synthesis, and evaluation of cyclofenil derivatives for potential SPECT imaging agents.
J Biol Inorg Chem
; 15(4): 591-9, 2010 May.
Article
en En
| MEDLINE
| ID: mdl-20195693
ABSTRACT
To develop technetium- and rhenium-labeled nonsteroidal estrogen imaging agents for estrogen receptor (ER) positive breast tumors, two groups of rhenium and technetium cyclofenil derivatives were synthesized and characterized. The binding affinities of the rhenium complexes for ERs were determined. The tricarbonyl rhenium complex showed the highest binding affinity for ERs (81.2 for ERbeta, 16.5 for ERalpha). Tricarbonyl technetium cyclofenil complexes were obtained in high radiochemical purity and radiochemical yields. The results of studies of their octanol/water partition and in vitro stability are presented. These results demonstrate that these radiolabeled cyclofenil derivatives may be considered as potential breast cancer imaging agents.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Diseño de Fármacos
/
Tomografía Computarizada de Emisión de Fotón Único
/
Ciclofenil
Límite:
Humans
Idioma:
En
Año:
2010
Tipo del documento:
Article