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Water-soluble PDE4 inhibitors for the treatment of dry eye.
Govek, Steven P; Oshiro, Guy; Anzola, John V; Beauregard, Clay; Chen, Jasmine; Coyle, Avery R; Gamache, Daniel A; Hellberg, Mark R; Hsien, Jennifer N; Lerch, Julia M; Liao, John C; Malecha, James W; Staszewski, Lena M; Thomas, David J; Yanni, John M; Noble, Stewart A; Shiau, Andrew K.
  • Govek SP; Kalypsys, Inc., 10420 Wateridge Circle, San Diego, CA 92121, United States. sgovek@san.rr.com
Bioorg Med Chem Lett ; 20(9): 2928-32, 2010 May 01.
Article en En | MEDLINE | ID: mdl-20378348
PDE4 inhibitors have the potential to alleviate the symptoms and underlying inflammation associated with dry eye. Disclosed herein is the development of a novel series of water-soluble PDE4 inhibitors. Our studies led to the discovery of coumarin 18, which is effective in a rabbit model of dry eye and a tear secretion test in rats.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Agua / 4-Aminopiridina / Cumarinas / Inhibidores de Fosfodiesterasa 4 / Antiinflamatorios Límite: Animals Idioma: En Año: 2010 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Agua / 4-Aminopiridina / Cumarinas / Inhibidores de Fosfodiesterasa 4 / Antiinflamatorios Límite: Animals Idioma: En Año: 2010 Tipo del documento: Article