[Oral cyclosporine microemulsion for the treatment of severe chronic idiopathic ulcerative colitis refractory to intravenous steroids: experience in two cases.]. / Ciclosporina oral en microemulsión para el tratamiento de la colitis ulcerativa crónica idiopática grave refractaria a esteroides intravenosos; experiencia en dos casos.

ABSTRACT

There have been important advances in the treatment of severe forms of ulcerative colitis (UC). They include biologic therapy and immunomodulators such as cyclosporine. The primary end-point of these therapies is to avoid colectomy in patients with severe disease when intravenous steroids have failed. Cyclosporine has been successful for induction of remission in severe UC, but undesirable side effects present quickly after intravenous delivery. We report two cases with severe UC that were successfully treated with oral microemulsion form of cyclosporine.