Cipura paludosa attenuates long-term behavioral deficits in rats exposed to methylmercury during early development.
Ecotoxicol Environ Saf
; 73(6): 1150-8, 2010 Sep.
Article
en En
| MEDLINE
| ID: mdl-20447691
ABSTRACT
In the present study, we evaluated the effects of the ethanolic extract (EE) of Cipura paludosa on locomotor, and anxiety- and depression-like behaviors of adult rats exposed to MeHg during early development. Additionally, the antioxidant enzymes catalase (CAT) and selenium-glutathione peroxidase (Se-GPx) were measured in cortical, hippocampal, and cerebellar tissues. Pregnant Wistar rats were treated by gavage with a single dose of MeHg (8 mg/kg) on gestational day 15, the developmental stage critical for cortical neuron proliferation. Moreover, prenatal MeHg exposure inhibited CAT and Se-GPx in the cortex and cerebellum. Chronic treatment with the EE of C. paludosa attenuated these emotional and antioxidant deficits induced by prenatal MeHg toxic exposure. This study provides novel evidence that developmental exposure to MeHg can affect not only cognitive functions but also locomotor, and anxiety- and depression-like behaviors.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
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Contaminantes Químicos del Agua
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Conducta Animal
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Extractos Vegetales
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Iridaceae
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Organogénesis
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Compuestos de Metilmercurio
Límite:
Animals
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Pregnancy
Idioma:
En
Año:
2010
Tipo del documento:
Article