Identification of valproic acid glucuronide hydrolase as a key enzyme for the interaction of valproic acid with carbapenem antibiotics.

Suzuki, Eiko; Yamamura, Naotoshi; Ogura, Yuji; Nakai, Daisuke; Kubota, Kazuishi; Kobayashi, Nobuhiro; Miura, Shin-ichi; Okazaki, Osamu

Suzuki, Eiko; Yamamura, Naotoshi; Ogura, Yuji; Nakai, Daisuke; Kubota, Kazuishi; Kobayashi, Nobuhiro; Miura, Shin-ichi; Okazaki, Osamu.

Suzuki E; Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-Ku, Tokyo, Japan. tsukada.eiko.x7@daiichisankyo.co.jp

Drug Metab Dispos ; 38(9): 1538-44, 2010 Sep.

Article en En | MEDLINE | ID: mdl-20551238

Asunto(s)

Antibacterianos/metabolismo; Glucurónidos/metabolismo; Hidrolasas/metabolismo; Ácido Valproico/metabolismo; Western Blotting; Glucuronidasa/metabolismo; Humanos; Hidrólisis; Hígado/enzimología

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácido Valproico / Glucurónidos / Hidrolasas / Antibacterianos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Año: 2010 Tipo del documento: Article

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