TMSG-1 and its roles in tumor biology.
Chin J Cancer
; 29(7): 697-702, 2010 Jul.
Article
en En
| MEDLINE
| ID: mdl-20591223
ABSTRACT
TMSG-1 is a newly discovered tumor metastasis suppressor gene, which plays important roles in promoting apoptosis and inhibiting invasion and metastasis of tumor cells. The inhibitory function of TMSG-1 in tumor cells may be related to vacuolar H+-ATPase and ceramide, but the underlying mechanism remains unknown. Studies on TMSG-1 are limited worldwide, and only a research group in Shanghai and our group have recently studied on it. As a new research field, the function of TMSG-1 remains to be explored. This review discusses the discovery of TMSG-1, structure of its encoded protein, its roles and possible mechanism in inhibiting tumor invasion and metastasis.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Ceramidas
/
ATPasas de Translocación de Protón Vacuolares
/
Proteínas Supresoras de Tumor
/
Esfingosina N-Aciltransferasa
/
Proteínas de la Membrana
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Año:
2010
Tipo del documento:
Article