Effects of endothelin-1 on arterial pressure and myocardial contractility in the conscious normotensive rabbit.
Clin Exp Pharmacol Physiol
; 18(5): 315-8, 1991 May.
Article
en En
| MEDLINE
| ID: mdl-2065476
ABSTRACT
1. We studied the effects of an intravenous bolus of endothelin-1 on arterial pressure and myocardial contractility in the conscious rabbit. 2. Endothelin produced an initial fall in arterial pressure accompanied by an increase in heart rate. This was followed by a dose-dependent increase in arterial pressure, peaking about 7 min after injection, accompanied by a reciprocal fall in heart rate. 3. Left ventricular rate of change of pressure (LV dP dt) increased with endothelin except at higher doses (0.8 and 1.6 nmol/kg), where in some animals it decreased.
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Banco de datos:
MEDLINE
Asunto principal:
Presión Sanguínea
/
Endotelinas
/
Contracción Miocárdica
Límite:
Animals
Idioma:
En
Año:
1991
Tipo del documento:
Article