A rabbit model for selective portal vein embolization.
J Surg Res
; 171(2): 486-94, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-20691990
ABSTRACT
BACKGROUND:
Portal vein embolization (PVE) is a technique to increase future remnant liver volume. A standardized animal model, resembling the clinical PVE procedure, is needed to clarify some of the unresolved issues surrounding PVE. For this purpose we developed a new rabbit model for PVE. MATERIALS ANDMETHODS:
Twenty female New Zealand white rabbits were allocated to two protocols, each containing two subgroups. Eighty percent of the liver portal venous system was embolized with polyvinyl-alcohol particles and coils (protocol 1 300-500 µm particles and one coil; protocol 2 90-180 µm combined 300-500 µm particles and three coils). In all rabbits CT-volumetry, ICG clearance test, blood sampling, and portography were performed prior to PVE and at d 7 and 14. Additional blood sampling and CT volumetry was done on d 3 and 7.RESULTS:
PVE was technically feasible in the rabbit. CT-volumetry demonstrated a strong correlation with actual liver weight and volume measured at sacrifice. The hypertrophy response was highest at d 7 in both protocols, which was consistent with the amount of proliferating hepatocytes. Protocol 2 showed less revascularization of the portal venous system and demonstrated the highest hypertrophy response. Comparable to the clinical situation, only a small, transient increase in transaminases was observed. There were no changes in liver function parameters after PVE. Histopathologic findings in the rabbit livers were comparable to those found in human livers.CONCLUSIONS:
We successfully devised a rabbit model for PVE, which resembles the human clinical situation.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vena Porta
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Conejos
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Modelos Animales
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Embolización Terapéutica
Tipo de estudio:
Guideline
/
Prognostic_studies
Límite:
Animals
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Female
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Humans
Idioma:
En
Año:
2011
Tipo del documento:
Article