Specific infiltration of langerin-positive dendritic cells in EBV-infected tonsil, Hodgkin lymphoma and nasopharyngeal carcinoma.
Int J Cancer
; 128(10): 2501-8, 2011 May 15.
Article
en En
| MEDLINE
| ID: mdl-20715107
ABSTRACT
We report here the existence of a novel subset of langerin (CD207)-positive, immature dendritic cells (DCs) (CD83(neg) ) abundantly infiltrating Epstein Barr virus (EBV)-infected areas in tonsil, Hodgkin lymphoma and nasopharyngeal carcinoma. These CD207(+) DCs differ from conventional epidermal Langerhans cells in their lack of CD1a and CCR6 and their unusual tissue localization. CD207(+) DC infiltration strongly correlates with EBV infection because it was neither detected in EBV negative specimens nor in tissues infected with other human viruses. These immature DCs might represent good candidates for induction of the EBV-specific immune response.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tonsila Palatina
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Células Dendríticas
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Enfermedad de Hodgkin
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Antígenos CD
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Neoplasias Nasofaríngeas
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Herpesvirus Humano 4
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Lectinas Tipo C
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Lectinas de Unión a Manosa
Límite:
Humans
Idioma:
En
Año:
2011
Tipo del documento:
Article