Evelynin, a cytotoxic benzoquinone-type Retro-dihydrochalcone from Tacca chantrieri.
J Nat Prod
; 73(9): 1590-2, 2010 Sep 24.
Article
en En
| MEDLINE
| ID: mdl-20715765
ABSTRACT
A new benzoquinone-type retro-dihydrochalcone, named evelynin, was isolated from the roots and rhizomes of Tacca chantrieri. The structure was elucidated on the basis of the analysis of spectroscopic data and confirmed by a simple one-step total synthesis. Evelynin exhibited cytotoxicity against four human cancer cell lines, MDA-MB-435 melanoma, MDA-MB-231 breast, PC-3 prostate, and HeLa cervical carcinoma cells, with IC(50) values of 4.1, 3.9, 4.7, and 6.3 µM, respectively.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Benzoquinonas
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Dioscoreaceae
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Chalconas
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Antineoplásicos Fitogénicos
Límite:
Female
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Humans
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Male
Idioma:
En
Año:
2010
Tipo del documento:
Article