Isolated central nervous system relapse in an adolescent with acute myelomonocytic leukemia, Charcot Marie Tooth syndrome, and paraneoplastic autoantibody.
J Pediatr Hematol Oncol
; 32(7): 571-3, 2010 Oct.
Article
en En
| MEDLINE
| ID: mdl-20724950
ABSTRACT
A 17-year-old boy, with acute myelomonocytic leukemia and inversion 16(p13q22) developed polyneuropathy and isolated central nervous system relapse. Scoliosis and high-arched feet suggested a diagnosis of Charcot Marie Tooth (CMT) syndrome and genetic testing confirmed duplication at the PMP22 locus at chromosome 17p11.12. No mutation was found in another CMT gene, the CMT C1 LITAF locus at 16p13.2, to suggest that this association is anything more than chance. Titres to VGKC, a paraneoplastic autoantibody, were elevated, suggesting an additional mechanism for the polyneuropathy. This case extends the clinical spectrum of cancer with CMT, and of paraneoplastic disorders.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
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Leucemia Mielomonocítica Aguda
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Enfermedad de Charcot-Marie-Tooth
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Síndromes Paraneoplásicos del Sistema Nervioso
Límite:
Adolescent
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Humans
/
Male
Idioma:
En
Año:
2010
Tipo del documento:
Article