Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding.
Lab Chip
; 10(20): 2655-8, 2010 Oct 21.
Article
en En
| MEDLINE
| ID: mdl-20820632
ABSTRACT
Minimally invasive biosensors are of great interest for rapid detection of disease biomarkers for diagnostic screening at the point-of-care. Here we introduce a device which extracts disease-specific biomarkers directly from the upper dermis, without the needle and syringe or resource-intensive blood processing. Using antigen-specific antibodies raised in mice as a model system, we confirm the analytical specificity and sensitivity of the antibody capture and extraction in comparison to the conventional methods based on needle/syringe blood draw followed by processing and antigen-specific ELISAs.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Piel
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Inmunoensayo
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Biomarcadores
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Técnicas Biosensibles
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Recolección de Muestras de Sangre
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Análisis por Matrices de Proteínas
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Técnicas Analíticas Microfluídicas
Límite:
Animals
Idioma:
En
Año:
2010
Tipo del documento:
Article