miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-ß.
Cell Res
; 20(10): 1158-69, 2010 Oct.
Article
en En
| MEDLINE
| ID: mdl-20856265
ABSTRACT
miR-142 and miR-223 have been identified as hematopoietic specific microRNAs. miR-223 has crucial functions in myeloid lineage development. However, the function of miR-142 remains unclear. In this study, we found that both miR-142 and miR-223 attenuated the proliferation of hematopoietic cells, and that miR-223 up-regulated miR-142 expression through the LMO2-L/-S isoforms and CEBP-ß. miR-223 negatively regulated both LMO2-L/-S isoforms and CEBP-ß post-transcriptionally, while CEBP-ß positively regulated the LMO2-L/-S isoforms and both of the LMO2-L/-S isoforms negatively regulated miR-142. These results reveal a novel miR-223--CEBP-ß--LMO2--miR-142 regulatory pathway, which has pivotal functions in hematopoiesis.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteína beta Potenciadora de Unión a CCAAT
/
MicroARNs
/
Proteínas de Unión al ADN
/
Metaloproteínas
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
2010
Tipo del documento:
Article