Cytogenetic instability in childhood acute lymphoblastic leukemia survivors.
J Biomed Biotechnol
; 20112011.
Article
en En
| MEDLINE
| ID: mdl-20871850
ABSTRACT
Contemporary anticancer therapies have largely improved the outcome for children with cancer, especially for Acute Lymphoblastic Leukemia (ALL). Actually, between 78% and 85% of patients achieve complete remission and are alive after 5 years of therapy completion. However, as cure rates increase, new concerns about the late effects of genotoxic treatment emerge, being the risk of developing secondary neoplasias, the most serious life-threatening rising problem. In the present paper, we describe and review the cytogenetic findings in peripheral lymphocytes from ALL survivors, and discuss aspects associated to the occurrence of increased chromosome rearrangements in this growing cohort.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aberraciones Cromosómicas
/
Sobrevivientes
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Child
/
Humans
Idioma:
En
Año:
2011
Tipo del documento:
Article