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Overexpression of transcription factor sp2 inhibits epidermal differentiation and increases susceptibility to wound- and carcinogen-induced tumorigenesis.
Kim, Tae-Hyung; Chiera, Shannon L; Linder, Keith E; Trempus, Carol S; Smart, Robert C; Horowitz, Jonathan M.
  • Kim TH; Department of Molecular Biomedical Sciences, Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina 27606, USA.
Cancer Res ; 70(21): 8507-16, 2010 Nov 01.
Article en En | MEDLINE | ID: mdl-20959487
Sp proteins are evolutionarily conserved transcription factors required for the expression of a wide variety of genes that are critical for development and cell cycle progression. Deregulated expression of certain Sp proteins is associated with the formation of a variety of human tumors; however, direct evidence that any given Sp protein is oncogenic has been lacking. Here, we report that Sp2 protein abundance in mice increases in concert with the progression of carcinogen-induced murine squamous cell carcinomas. Transgenic mice specifically overexpressing murine Sp2 in epidermal basal keratinocytes were highly susceptible to wound- and carcinogen-induced papillomagenesis. Transgenic animals that were homozygous rather than hemizygous for the Sp2 transgene exhibited a striking arrest in the epidermal differentiation program, perishing within 2 weeks of birth. Our results directly support the likelihood that Sp2 overexpression occurring in various human cancers has significant functional effect.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Heridas y Lesiones / Carcinoma de Células Escamosas / Diferenciación Celular / 9,10-Dimetil-1,2-benzantraceno / Factor de Transcripción Sp2 / Células Epidérmicas Tipo de estudio: Etiology_studies Límite: Animals / Female / Humans / Male Idioma: En Año: 2010 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Heridas y Lesiones / Carcinoma de Células Escamosas / Diferenciación Celular / 9,10-Dimetil-1,2-benzantraceno / Factor de Transcripción Sp2 / Células Epidérmicas Tipo de estudio: Etiology_studies Límite: Animals / Female / Humans / Male Idioma: En Año: 2010 Tipo del documento: Article