Characterization and mode of inheritance of a paroxysmal dyskinesia in Chinook dogs.
J Vet Intern Med
; 24(6): 1305-13, 2010.
Article
en En
| MEDLINE
| ID: mdl-21054538
ABSTRACT
BACKGROUND:
Paroxysmal dyskinesias are episodes of abnormal, involuntary movement or muscle tone, distinguished from seizures by the character of the episode and lack of seizure activity on ictal EEG.HYPOTHESIS:
Paroxysmal dyskinesia is an inherited, autosomal recessive disorder in Chinook dogs. ANIMALS Families of Chinook dogs with paroxysmal dyskinesia.METHODS:
Pedigrees and medical histories were reviewed for 299 Chinook dogs. A family of 51 dogs was used for analysis. Episodes were classified as seizures, paroxysmal dyskinesia, or unknown, and segregation analysis was performed.RESULTS:
Paroxysmal dyskinesia was identified in 16 of 51 dogs and characterized by an inability to stand or ambulate, head tremors, and involuntary flexion of 1 or multiple limbs, without autonomic signs or loss of consciousness. Episode duration varied from minutes to an hour. Inter-ictal EEGs recorded on 2 dogs with dyskinesia were normal. Three dogs with dyskinesia also had generalized tonic-clonic seizures. One of 51 dogs had episodes of undetermined type. Phenotype was unknown for 6 of 51 dogs, and 28 dogs were unaffected. Segregation was consistent with an autosomal recessive trait. CONCLUSIONS AND CLINICAL IMPORTANCE This movement disorder is prevalent in the Chinook breed, and consistent with a partially penetrant autosomal recessive or polygenic trait. Insufficient evidence exists for definitive localization; episodes may be of basal nuclear origin, but atypical seizures and muscle membrane disorders remain possible etiologies. The generalized seizures may be a variant phenotype of the same mutation that results in dyskinesia, or the 2 syndromes may be independent.
Texto completo:
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Banco de datos:
MEDLINE
Asunto principal:
Corea
/
Predisposición Genética a la Enfermedad
/
Enfermedades de los Perros
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2010
Tipo del documento:
Article