Brain death provokes very acute alteration in myocardial morphology detected by echocardiography: preventive effect of beta-blockers.
Transpl Int
; 24(3): 300-6, 2011 Mar.
Article
en En
| MEDLINE
| ID: mdl-21083628
ABSTRACT
Our objective was to evaluate immediate acute changes in myocardial function during the autonomic storm of brain death (BD). Wistar rats were divided into four groups (n = 8/group) controls without any treatment, ß-blocker (Esmolol®, 10 mg/kg), calcium channel blocker (Diltiazem®, 10 mg/kg), or alpha-blocker (Prazosin®, 0.3 mg/kg). Treatments were administered intravenously 5 min before BD induction. Echocardiography (ATL-5000, 8 MHz) was performed to measure left ventricular (LV) dimensions and fractional shortening at baseline, during BD induction and 5 min and 15 min after BD. In controls, BD was immediately associated with an increase in wall thickness and a decrease in LV cavity dimension. This myocardial wall hypertrophy was completely prevented by ß-blockers, but not with calcium- and alpha-blockers. Extensive myocardial interstitial edema was found in all groups, except in the ß-blocker group. Myocardial wall hypertrophy was also prevented during a longer follow-up of 180 min after BD in ß-blocker group as opposed to controls. In conclusion, BD is associated with an immediate and severe myocardial damage related to an important interstitial edema which is prevented by ß-blockers.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Propanolaminas
/
Muerte Encefálica
/
Antagonistas Adrenérgicos beta
/
Miocardio
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Año:
2011
Tipo del documento:
Article