Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability.

Shaw, Bryan F; Arthanari, Haribabu; Narovlyansky, Max; Durazo, Armando; Frueh, Dominique P; Pollastri, Michael P; Lee, Andrew; Bilgicer, Basar; Gygi, Steven P; Wagner, Gerhard; Whitesides, George M

Shaw, Bryan F; Arthanari, Haribabu; Narovlyansky, Max; Durazo, Armando; Frueh, Dominique P; Pollastri, Michael P; Lee, Andrew; Bilgicer, Basar; Gygi, Steven P; Wagner, Gerhard; Whitesides, George M.

Shaw BF; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA. bryan_shaw@baylor.edu

J Am Chem Soc ; 132(49): 17411-25, 2010 Dec 15.

Article en En | MEDLINE | ID: mdl-21090618

Asunto(s)

Amidas/química; Anhidrasa Carbónica II/química; Hidrógeno/química; Acetilación; Animales; Bovinos; Interacciones Hidrofóbicas e Hidrofílicas; Lisina/química; Espectrometría de Masas; Resonancia Magnética Nuclear Biomolecular; Conformación Proteica; Estabilidad Proteica; Electricidad Estática; Temperatura

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Anhidrasa Carbónica II / Amidas / Hidrógeno Límite: Animals Idioma: En Año: 2010 Tipo del documento: Article

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