The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice.
Mem Inst Oswaldo Cruz
; 105(7): 945-8, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-21120371
ABSTRACT
The activity of the antineoplastic drug tamoxifen was evaluated against Trypanosoma cruzi. In vitro activity was determined against epimastigote, trypomastigote and amastigote forms of CL14, Y and Y benznidazole resistant T. cruzi strains. Regardless of the strain used, the drug was active against all life-cycle stages of the parasite with a half maximal effective concentration ranging from 0.7-17.9 µM. Two experimental models of acute Chagas disease were used to evaluate the in vivo efficacy of treatment with tamoxifen. No differences in parasitemia and mortality were observed between control mock-treated and tamoxifen-treated mice.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tamoxifeno
/
Tripanocidas
/
Trypanosoma cruzi
/
Enfermedad de Chagas
Límite:
Animals
Idioma:
En
Año:
2010
Tipo del documento:
Article