Immune reconstitution inflammatory syndrome mimicking relapsing cryptococcal meningitis in a renal transplant recipient.
Transpl Infect Dis
; 13(3): 303-8, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21159113
ABSTRACT
Immune reconstitution inflammatory syndrome (IRIS) is a rare entity that has been described recently in solid organ transplant (SOT) recipients. IRIS is characterized by an exuberant and dysregulated immune response following treatment of opportunistic infections. We describe here the case of a kidney transplant recipient who developed cryptococcal meningitis that was efficiently treated with antifungal therapy and decreased immunosuppression regimen. Eight months later, a paradoxical worsening of neurological symptoms and neuroradiological findings led to the diagnosis of IRIS. A short course of high-dose steroid therapy allowed complete resolution of neurological symptoms. This report highlights the challenge for physicians to distinguish IRIS from a relapsing cryptococcal infection. Clinical improvement of cryptococcosis-associated IRIS by anti-inflammatory drugs needs to be confirmed among SOT recipients.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Riñón
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Meningitis Criptocócica
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Corticoesteroides
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Síndrome Inflamatorio de Reconstitución Inmune
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Humans
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Male
/
Middle aged
Idioma:
En
Año:
2011
Tipo del documento:
Article