Direct compression high functionality excipient using coprocessing technique: a brief review.
Curr Drug Deliv
; 8(4): 426-35, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-21235470
ABSTRACT
Tablets are still the most commonly used dosage form because of the ease of manufacturing, convenience in administration, accurate dosing and excellent stability. Direct compression is the preferred method for the preparation of tablets. However, it has been estimated that less than 20 percent of the active pharmaceutical ingredients (API) can be processed into tablets via direct compression since the majority of API lack the flow, cohesion or lubricating properties required for direct compression. Increasing trends toward direct compression suggests the need for development of high functional excipients. High functionality of excipients can be obtained by development of new excipients or by particle engineering of existing excipients. Particle engineering using coprocessing provides a way to obtain an excipient with high functionality. Coprocessed excipients are the mixture of two or more excipients interacting at sub-particle level; that can provide an excipient with improved functionality as well as masking undesirable properties. Coprocessing is very cost effective method of providing high functional excipient. The present review discusses the advantages of coprocessed excipients, role of material science in coprocessing, methods of coprocessing of excipients and properties of various coprocessed excipients available in the market.
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Banco de datos:
MEDLINE
Asunto principal:
Comprimidos
/
Química Farmacéutica
/
Excipientes
Límite:
Humans
Idioma:
En
Año:
2011
Tipo del documento:
Article