Discovery and characterization of a unique mycobacterial heme acquisition system.
Proc Natl Acad Sci U S A
; 108(12): 5051-6, 2011 Mar 22.
Article
en En
| MEDLINE
| ID: mdl-21383189
ABSTRACT
Mycobacterium tuberculosis must import iron from its host for survival, and its siderophore-dependent iron acquisition pathways are well established. Here we demonstrate a newly characterized pathway, whereby M. tuberculosis can use free heme and heme from hemoglobin as an iron source. Significantly, we identified the genomic region, Rv0202c-Rv0207c, responsible for the passage of heme iron across the mycobacterial membrane. Key players of this heme uptake system were characterized including a secreted protein and two transmembrane proteins, all three specific to mycobacteria. Furthermore, the crystal structure of the key heme carrier protein Rv0203 was found to have a unique fold. The discovery of a unique mycobacterial heme acquisition pathway opens new avenues of exploration into mycobacterial therapeutics.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Proteínas Portadoras
/
Hemo
/
Hierro
/
Mycobacterium tuberculosis
Idioma:
En
Año:
2011
Tipo del documento:
Article