Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A.
J Nat Prod
; 74(5): 1272-4, 2011 May 27.
Article
en En
| MEDLINE
| ID: mdl-21504214
ABSTRACT
A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar antifungal activity against Saccharomyces cerevisiae, but, interestingly, approximately twice the cytostatic activity against human small-cell lung cancer cells. The production of 2,3-dihydrotrichostatin A via microbial biotransformation demonstrates that the regiospecific and substrate-flexible hydrogenation by S. venezuelae provides a new approach for creating natural product analogues with improved bioactive properties.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Saccharomyces cerevisiae
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Streptomyces
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Productos Biológicos
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Ácidos Hidroxámicos
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Antifúngicos
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Antineoplásicos
Límite:
Humans
Idioma:
En
Año:
2011
Tipo del documento:
Article