The Th1 life cycle: molecular control of IFN-γ to IL-10 switching.
Trends Immunol
; 32(6): 278-86, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21531623
ABSTRACT
Control of IFN-γ-secreting T helper (Th) 1 cells prevents autoimmunity and immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not only through IL-10 produced extrinsically, but also through a negative feedback loop that induces "intrinsic" IL-10 expression in cells also expressing IFN-γ, during Th1 lineage differentiation. Targeting this Th1 cell IFN-γ to IL-10 switching is a tantalising prospect for developing therapeutics for Th1-mediated diseases. In this review, the molecular pathways that regulate IFN-γ versus IL-10 expression in Th1 cells are examined, with focus on the role of complement regulator and T cell co-stimulatory molecule CD46, and also discussed are challenges and controversies in the field.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Interferón gamma
/
Interleucina-10
/
Células TH1
Límite:
Animals
/
Humans
Idioma:
En
Año:
2011
Tipo del documento:
Article