Carcinogenic and genotoxic activity of extracts from contaminated sediments in western Lake Ontario.
Sci Total Environ
; 94(1-2): 125-41, 1990 May 01.
Article
en En
| MEDLINE
| ID: mdl-2163105
ABSTRACT
In order to investigate the putative association between chemical contamination in western Lake Ontario and high prevalences of fish tumors, sediments from Hamilton Harbour and Oakville Creek in Lake Ontario and reference sites in non-polluted areas of Ontario, Canada were collected and extracted for organic contaminants. Sediment extracts from Hamilton Harbour had the highest concentrations of polychlorinated biphenyls and organochlorine insecticides (ppb) and contained very high concentrations of polynuclear aromatic hydrocarbons (ppm); although the levels of these compounds varied widely with sampling location in the harbor. A sediment extract from Hamilton Harbour was mutagenic in the Ames bacterial assay, both with and without microsomal activation. High levels of aromatic DNA adducts were induced in cultured mouse C3H1OT1/2 cells after in vitro exposure to Hamilton Harbour sediment extract. In two separate carcinogenicity experiments involving a sac fry microinjection assay with rainbow trout (Oncorhynchus mykiss), Hamilton Harbour sediment extract induced hepatocellular carcinomas in fish. No hepatic neoplasms were observed in fish that had been treated with sediment extract from Oakville Creek, or with extract from a reference sediment. The significance of these results is discussed in relation to the distribution of neoplasms in feral fish within western Lake Ontario.
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Banco de datos:
MEDLINE
Asunto principal:
Contaminantes del Agua
/
Contaminantes Químicos del Agua
/
Carcinógenos
/
Carcinoma Hepatocelular
/
Enfermedades de los Peces
/
Neoplasias Hepáticas
/
Mutágenos
/
Neoplasias
Límite:
Animals
País como asunto:
America do norte
Idioma:
En
Año:
1990
Tipo del documento:
Article