GnRH receptor mutations in isolated gonadotropic deficiency.
Mol Cell Endocrinol
; 346(1-2): 21-8, 2011 Oct 22.
Article
en En
| MEDLINE
| ID: mdl-21645587
ABSTRACT
GnRH and its receptor GnRHR are key regulators of the hypothalamo-pituitary axis. They modulate the secretion of LH and FSH gonadotropins and therefore, the development and maturation of gonads in fetal life as well as after birth. Congenital functional defect of this axis results in isolated hypogonadotropic hypogonadism (IHH). Several natural mutations causing IHH without anosmia have now been identified in GnRHR or GnRH genes. These mutations inactivate GnRHR or its ligand function and cause highly variable phenotypes, ranging from partial to complete gonadotropic deficiencies. The present review describes the published natural GnRHR mutations and tries to correlate them with the corresponding phenotypes according to the different steps of the GnRH system development.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Hormona Liberadora de Gonadotropina
/
Receptores LHRH
/
Mutación
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2011
Tipo del documento:
Article