Inhibitory effect of gossypol on human chorionic gonadotropin (hCG)-induced progesterone secretion in cultured bovine luteal cells.
Life Sci
; 47(5): 407-14, 1990.
Article
en En
| MEDLINE
| ID: mdl-2168511
ABSTRACT
Inhibitory effects of gossypol on the female reproductive system have been recently reported. This study investigated a possible site of gossypol action on progesterone synthesis. Bovine luteal cells were cultured with hCG and forskolin in the presence or absence of gossypol. At 10 micrograms/ml, gossypol significantly inhibited hCG- and forskolin-stimulated progesterone secretion and intracellular cAMP formation; at 20 micrograms/ml, gossypol completely abolished the stimulative effect of hCG and forskolin. The results suggest that adenylate cyclase may be a site of gossypol action on steroidogenesis of bovine luteal cells.
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Banco de datos:
MEDLINE
Asunto principal:
Progesterona
/
Gosipol
/
Cuerpo Lúteo
/
Gonadotropina Coriónica
/
Células Lúteas
Límite:
Animals
Idioma:
En
Año:
1990
Tipo del documento:
Article