Taurine: stimulation of pineal N-acetyltransferase activity and melatonin production via a beta-adrenergic mechanism.
Brain Res
; 166(1): 65-74, 1979 Apr 20.
Article
en En
| MEDLINE
| ID: mdl-217502
ABSTRACT
Pineal glands convert [3H]tryptophan to [3H]N-acetylserotonin and [3H]melatonin in organ culture. Taurine treatment increases the rate of production of these compounds 40- and 25-fold respectively by stimulating the activity of N-acetyltransferase. This stimulation is blocked stereospecifically by L-propranolol, indicating that taurine is probably acting via beta-adrenergic receptors. Taurine is active in stimulating N-acetyltransferase activity in denervated glands, suggesting that it might interact directly with the beta-adrenergic receptor, and not by causing the release of norepinephrine from nerve terminals.
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Banco de datos:
MEDLINE
Asunto principal:
Glándula Pineal
/
Acetiltransferasas
/
Taurina
/
Receptores Adrenérgicos
/
Receptores Adrenérgicos beta
/
Melatonina
Límite:
Animals
Idioma:
En
Año:
1979
Tipo del documento:
Article