Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations.
PLoS Genet
; 7(7): e1002170, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-21814517
ABSTRACT
Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10(-8)) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined)â=â2.3×10(-10), odds ratio [OR]â=â1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201 Pâ=â5.5×10(-10), ORâ=â1.52, and DPB1*0901 Pâ=â2.0×10(-7), ORâ=â1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations.
Texto completo:
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Banco de datos:
MEDLINE
Asunto principal:
Asma
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Antígenos HLA-DP
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Predisposición Genética a la Enfermedad
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Pueblo Asiatico
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Año:
2011
Tipo del documento:
Article