Antimalarial action of flavin analogues seems not be due to inhibition of glutathione reductase of host erythrocytes.
Biochem Pharmacol
; 39(6): 1063-5, 1990 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-2182031
ABSTRACT
A series of 10-(4'-chlorophenyl)-3-substituted flavins (1a-f) were examined with respect to their antimalarial properties. They were tested against Plasmodium falciparum in vitro and Plasmodium vinckei vinckei in vivo. The proposition that they might act through glutathione reductase (GR) (EC 1.6.4.2) inhibition has been studied. Inhibition of P. falciparum in vitro by these compounds shows only slight variation between analogues; in contrast, inhibition of human erythrocyte GR by members of the same series is highly variable, indicating that this is probably not their primary mode of antimalarial action. Results of the P. vinckei vinckei screen showed that 10-(4'-chlorophenyl)-3-methyl,3-ethyl and 3-propyl substituted flavins are active in vivo over the dose range screened (10-70 mg/kg).
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Riboflavina
/
Eritrocitos
/
Glutatión Reductasa
/
Antimaláricos
Límite:
Animals
/
Humans
Idioma:
En
Año:
1990
Tipo del documento:
Article