Vessel resistance to blood flow in the nailfold in patients with psoriasis: a prospective case-control echo Doppler-based study.
Br J Dermatol
; 166(1): 54-8, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-21848688
ABSTRACT
BACKGROUND:
Psoriasis is a disease in which endothelial cells seem to play an important pathogenic role. No report published to date has examined nail vascularity in patients with psoriasis.OBJECTIVES:
To evaluate the vascularity in the nails of patients with psoriasis treated with classic and biologic therapies for comparison with disease-free controls, and to evaluate whether there are differences in nail vascularity among patients with and without nail involvement.METHODS:
We performed a prospective study with two cohorts comprising 23 patients with moderate-to-severe psoriasis and 23 controls without psoriasis. We measured the nailfold vessel resistance index (NVRI) in each subgroup.RESULTS:
We found significant differences in the NVRI between patients and controls (P<0·001). Among patients with psoriasis, those with nail involvement showed a higher mean±SD NVRI (0·58±0·10) than those without (0·52±0·45).CONCLUSIONS:
Psoriasis decreases the blood flow in nails, suggesting that this skin disease confers an independent risk for microvascular changes. This outcome may be associated with greater risk of nail-related signs.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Psoriasis
/
Resistencia Vascular
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Enfermedades de la Uña
/
Uñas
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Año:
2012
Tipo del documento:
Article