[Preventive efficacy of ondansetron and granisetron for postoperative nausea and vomiting in high risk patients].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
; 33(4): 445-8, 2011 Aug.
Article
en Zh
| MEDLINE
| ID: mdl-21906457
ABSTRACT
OBJECTIVE:
To compare the efficacy of ondansetron and granisetron in the prevention of postoperative nausea and vomiting (PONV) in high-risk patients.METHODS:
Totally 200 patients with three key risk factors for PONV (female, non-smoking and postoperative opioid use) were equally randomized into ondansetron group and granisetron group. Ondansetron (4 mg) or granisetron (3 mg) was intravenously administered upon the completion of surgery. The episodes of nausea and vomiting were observed for 24 hours after surgery.RESULTS:
A significantly greater proportion of patients in granisetron group achieved a complete response (i.e., no PONV or rescue medication) during the first 24 hours postoperatively versus those in ondansetron group (62.6% vs. 46.9%, respectively; P=0.048). There were no significant differences in terms of postoperative nausea incidences (42.9% vs. 34.3%, respectively), postoperative vomiting incidences (25.5% vs. 20.2%, respectively) and postoperative rescue anti-emetics incidences (19.4% vs. 15.2%, respectively) (P>0.05).CONCLUSION:
Granisetron is more effective than ondansetron in preventing PONV in high-risk patients during the first 24 hours postoperatively.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ondansetrón
/
Granisetrón
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Náusea y Vómito Posoperatorios
Tipo de estudio:
Clinical_trials
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Etiology_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
Zh
Año:
2011
Tipo del documento:
Article