Baseline in vitro activities of the antimalarials pyronaridine and methylene blue against Plasmodium falciparum isolates from Kenya.
Antimicrob Agents Chemother
; 56(2): 1105-7, 2012 Feb.
Article
en En
| MEDLINE
| ID: mdl-22123687
ABSTRACT
We have analyzed the in vitro activities of pyronaridine and methylene blue against 59 Plasmodium falciparum isolates from Kenya in association with polymorphisms in Pfcrt (codon 76), Pfmdr1 (codon 86), and Pfnhe (full sequence). The median inhibitory concentrations that kill 50% of parasites were 13.5 and 3.3 nM for pyronaridine and methylene blue, respectively. Their activities were not associated with polymorphisms in these genes. The drugs' high in vitro activities indicate that they would be efficacious against Kenyan isolates in vivo.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
/
Malaria Falciparum
/
Azul de Metileno
/
Naftiridinas
/
Antimaláricos
Límite:
Animals
/
Humans
País como asunto:
Africa
Idioma:
En
Año:
2012
Tipo del documento:
Article