Distribution of HPV genotypes in Slovenian patients with anal carcinoma: preliminary results.
Acta Dermatovenerol Alp Pannonica Adriat
; 20(3): 141-3, 2011 Sep.
Article
en En
| MEDLINE
| ID: mdl-22131114
ABSTRACT
The aim of the present study was to obtain first data on the distribution of human papillomavirus (HPV) genotypes in patients with anal cancer (AC) in Slovenia. A total of 21 samples of AC (16 archival FFPE samples and 5 fresh-frozen tissue samples) collected from the same number of patients were analysed. All samples were tested for the presence of HPV DNA using a consensus GP5+/ GP6+ PCR and HPV genotypes determined by the INNO LiPA HPV Genotyping Extra test, capable of recognizing 28 different alfa-HPV genotypes. All 21 AC samples were HPV DNA positive. The most frequent HPV genotype, found in 19/21 AC samples, was HPV-16. Only low-risk HPV-6 was detected in one sample and infection with high-risk HPV-52 and low-risk HPV-61 was identified in one sample. Prophylactic HPV vaccination with currently available vaccines could potentially prevent the great majority of anal cancers in Slovenia.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias del Ano
/
Papillomaviridae
Tipo de estudio:
Prevalence_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
País como asunto:
Europa
Idioma:
En
Año:
2011
Tipo del documento:
Article