TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-ß signaling.
BMC Cancer
; 11: 507, 2011 Dec 05.
Article
en En
| MEDLINE
| ID: mdl-22142399
ABSTRACT
BACKGROUND:
TMPRSS2-ERG gene fusions occur in about 50% of all prostate cancer cases and represent promising markers for molecular subtyping. Although TMPRSS2-ERG fusion seems to be a critical event in prostate cancer, the precise functional role in cancer development and progression is still unclear.METHODS:
We studied large-scale gene expression profiles in 47 prostate tumor tissue samples and in 48 normal prostate tissue samples taken from the non-suspect area of clinical low-risk tumors using Affymetrix GeneChip Exon 1.0 ST microarrays.RESULTS:
Comparison of gene expression levels among TMPRSS2-ERG fusion-positive and negative tumors as well as benign samples demonstrated a distinct transcriptional program induced by the gene fusion event. Well-known biomarkers for prostate cancer detection like CRISP3 were found to be associated with the gene fusion status. WNT and TGF-ß/BMP signaling pathways were significantly associated with genes upregulated in TMPRSS2-ERG fusion-positive tumors.CONCLUSIONS:
The TMPRSS2-ERG gene fusion results in the modulation of transcriptional patterns and cellular pathways with potential consequences for prostate cancer progression. Well-known biomarkers for prostate cancer detection were found to be associated with the gene fusion. Our results suggest that the fusion status should be considered in retrospective and future studies to assess biomarkers for prostate cancer detection, progression and targeted therapy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
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Biomarcadores de Tumor
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Proteínas de Fusión Oncogénica
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Factor de Crecimiento Transformador beta
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Perfilación de la Expresión Génica
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
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Male
Idioma:
En
Año:
2011
Tipo del documento:
Article