MKP-2: out of the DUSP-bin and back into the limelight.
Biochem Soc Trans
; 40(1): 235-9, 2012 Feb.
Article
en En
| MEDLINE
| ID: mdl-22260697
ABSTRACT
The MKPs (mitogen-activated protein kinase phosphatases) are a family of at least ten DUSPs (dual-specificity phosphatases) which function to terminate the activity of the MAPKs (mitogen-activated protein kinases). Several members have already been demonstrated to have distinct roles in immune function, cancer, fetal development and metabolic disorders. One DUSP of renewed interest is the inducible nuclear phosphatase MKP-2, which dephosphorylates both ERK (extracellular-signal-regulated kinase) and JNK (c-Jun N-terminal kinase) in vitro. Recently, the understanding of MKP-2 function has been advanced due to the development of mouse knockout models, which has resulted in the discovery of novel roles for MKP-2 in the regulation of sepsis, infection and cell-cycle progression that are distinct from those of other DUSPs. However, many functions for MKP-2 still await to be characterized.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fosfatasas de la Proteína Quinasa Activada por Mitógenos
/
Fosfatasas de Especificidad Dual
Límite:
Animals
/
Humans
Idioma:
En
Año:
2012
Tipo del documento:
Article