Divergent outcomes of gold(I)-catalyzed indole additions to 3,3-disubstituted cyclopropenes.

Young, Paul C; Hadfield, Maximillian S; Arrowsmith, Lynn; Macleod, Kristina M; Mudd, Richard J; Jordan-Hore, James A; Lee, Ai-Lan

Young, Paul C; Hadfield, Maximillian S; Arrowsmith, Lynn; Macleod, Kristina M; Mudd, Richard J; Jordan-Hore, James A; Lee, Ai-Lan.

Young PC; School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, Scotland, United Kingdom.

Org Lett ; 14(3): 898-901, 2012 Feb 03.

Article en En | MEDLINE | ID: mdl-22272604

ABSTRACT

ABSTRACT

Depending on the conditions employed, gold(I)-catalyzed addition of indoles to 3,3-disubstituted cyclopropenes can be controlled to yield either 3-(E)-vinylindoles (3) or bis-indolylalkanes (4). If the cyclopropene substituents are sterically bulky, unprecedented gold-catalyzed oxidation under air occurs to yield bis-indolylalkene (5) and epoxide (6) at room temperature.

Asunto(s)

Ciclopropanos/química; Oro/química; Indoles/química; Catálisis; Estructura Molecular; Oxidación-Reducción

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ciclopropanos / Oro / Indoles Idioma: En Año: 2012 Tipo del documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ciclopropanos / Oro / Indoles Idioma: En Año: 2012 Tipo del documento: Article