Electrical brain stimulation improves cognitive performance by modulating functional connectivity and task-specific activation.
J Neurosci
; 32(5): 1859-66, 2012 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-22302824
ABSTRACT
Excitatory anodal transcranial direct current stimulation (atDCS) can improve human cognitive functions, but neural underpinnings of its mode of action remain elusive. In a cross-over placebo ("sham") controlled study we used functional magnetic resonance imaging (fMRI) to investigate neurofunctional correlates of improved language functions induced by atDCS over a core language area, the left inferior frontal gyrus (IFG). Intrascanner transcranial direct current stimulation-induced changes in overt semantic word generation assessed behavioral modulation; task-related and task-independent (resting-state) fMRI characterized language network changes. Improved word-retrieval during atDCS was paralleled by selectively reduced task-related activation in the left ventral IFG, an area specifically implicated in semantic retrieval processes. Under atDCS, resting-state fMRI revealed increased connectivity of the left IFG and additional major hubs overlapping with the language network. In conclusion, atDCS modulates endogenous low-frequency oscillations in a distributed set of functionally connected brain areas, possibly inducing more efficient processing in critical task-relevant areas and improved behavioral performance.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Desempeño Psicomotor
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Encéfalo
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Cognición
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Estimulación Encefálica Profunda
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Red Nerviosa
Tipo de estudio:
Clinical_trials
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Año:
2012
Tipo del documento:
Article