Novel substituted 9-norbornylpurines and their activities against RNA viruses.
Bioorg Med Chem Lett
; 22(5): 1963-8, 2012 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-22310228
ABSTRACT
We report on the synthesis and the study of the structure-activity relationship of novel 9-norbornyl-6-chloropurine derivatives, which exert selective antiviral activity on the replication of Coxsackievirus B3. In particular, the synthetic approaches towards norbornyl derivatives bearing diverse side chains were studied. The main goal of the study was to determine the influence of the norbornane moiety substitution at positions 5' and 6' on selective antiviral activity with special regard to the liphophilicity profile of the substituent.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Purinas
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Enterovirus Humano B
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Norbornanos
Límite:
Animals
/
Humans
Idioma:
En
Año:
2012
Tipo del documento:
Article