Yeast colonization of voice prostheses: pilot study investigating effect of a bovine milk product containing anti-Candida albicans immunoglobulin A antibodies on yeast colonization and valve leakage.
Ann Otol Rhinol Laryngol
; 121(1): 61-6, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-22312930
ABSTRACT
OBJECTIVES:
Our goals were to determine whether a bovine milk product containing anti-Candida albicans immunoglobulin A antibodies ("immune milk") could reduce the adherence of C albicans to voice prosthesis silicone in vitro, and whether administration of the milk could reduce C albicans colonization and voice prosthesis damage in vivo.METHODS:
An in vitro assay of C albicans attachment to silicone was developed with radiolabeled C albicans. A pilot crossover in vivo trial, over 3 periods of 3 months, was also undertaken for 4 patients with voice prostheses, comparing daily administrations of immune milk and a control milk product. The prosthesis valves were replaced at each changeover and were assessed for wet weight of removable biofilm, yeast numbers in removable biofilm, valve leakage, and valve damage.RESULTS:
Immune milk inhibited C albicans adherence to silicone in vitro. However, in a small clinical pilot study, this effect was not replicated.CONCLUSIONS:
There is scope to further investigate the topical use of immune milk for management of voice prosthesis biofilms.
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Banco de datos:
MEDLINE
Asunto principal:
Candida albicans
/
Inmunoglobulina A
/
Contaminación de Equipos
/
Biopelículas
/
Leche
/
Laringe Artificial
Límite:
Animals
/
Humans
Idioma:
En
Año:
2012
Tipo del documento:
Article