[Establishment of tree shrew chronic morphine dependent model].
Dongwuxue Yanjiu
; 33(1): 14-8, 2012 Feb.
Article
en Zh
| MEDLINE
| ID: mdl-22345003
ABSTRACT
The clinical use of morphine to reduce pain is limited because of its drug tolerance, dependence and addiction. In the present study, the tree shrews (Tupaia belangeri chinensis) developed morphine tolerance and chronic morphine dependence by morphine injections with increasing doses (5, 10, 15, 20 mg/kg body weight for 7 days). Meanwhile, the naloxone (1.25 mg/kg body weight)-induced conditioned place aversion (CPA) and the withdrawal symptom were also found. The tree shrew model of chronic morphine dependence can be used to investigate the withdrawal symptoms and to select potential withdrawal symptoms reducing drugs in the future.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Dolor
/
Síndrome de Abstinencia a Sustancias
/
Tupaia
/
Modelos Animales de Enfermedad
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Morfina
/
Dependencia de Morfina
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
/
Male
Idioma:
Zh
Año:
2012
Tipo del documento:
Article