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Phase I safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mTOR inhibitor BGT226 in patients with advanced solid tumors.
Markman, B; Tabernero, J; Krop, I; Shapiro, G I; Siu, L; Chen, L C; Mita, M; Melendez Cuero, M; Stutvoet, S; Birle, D; Anak, Ö; Hackl, W; Baselga, J.
  • Markman B; Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Tabernero J; Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Krop I; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA.
  • Shapiro GI; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA.
  • Siu L; Department of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Canada.
  • Chen LC; Nevada Cancer Institute, Las Vegas.
  • Mita M; Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, San Antonio, USA.
  • Melendez Cuero M; Oncology Translational Medicine, Novartis Pharma AG, Basel, Switzerland.
  • Stutvoet S; Oncology Translational Medicine, Novartis Pharma AG, Basel, Switzerland.
  • Birle D; Novartis Institutes for Biomedical Research, Cambridge, USA.
  • Anak Ö; Oncology Translational Medicine, Novartis Pharma AG, Basel, Switzerland.
  • Hackl W; Oncology Translational Medicine, Novartis Pharma AG, Basel, Switzerland.
  • Baselga J; Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: jbaselga@partners.org.
Ann Oncol ; 23(9): 2399-2408, 2012 Sep.
Article en En | MEDLINE | ID: mdl-22357447
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Quinolinas / Neoplasias de la Mama / Neoplasias del Colon / Imidazoles / Antineoplásicos Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2012 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Quinolinas / Neoplasias de la Mama / Neoplasias del Colon / Imidazoles / Antineoplásicos Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2012 Tipo del documento: Article