Apoptin induces apoptosis in human bladder cancer EJ and BIU-87 cells.
Asian Pac J Cancer Prev
; 13(1): 135-8, 2012.
Article
en En
| MEDLINE
| ID: mdl-22502656
ABSTRACT
OBJECTIVE:
To investigate whether apoptin is a apoptosis-inducing protein with a potential for bladder cancer therapy.METHODS:
We constructed a PCDNA3/Apoptin eukaryotic expression vector, and transfected this vector into bladder cancer cell lines BIU-87 and EJ, then observed the results by RT-PCR, transmission electron microscopy, MTT assay and the flow cytometry (TUNEL method).RESULTS:
PCDNA3/Apoptin successfully induced a high level apoptosis in both bladder cancer cell lines, compared with the controls (p<0.05).CONCLUSIONS:
Apoptin can induce high level apoptosis in human bladder cancer EJ and BIU-87 cells, which suggests a potential for human bladder cancer therapy.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Vejiga Urinaria
/
Apoptosis
/
Proteínas de la Cápside
/
Proliferación Celular
Límite:
Humans
Idioma:
En
Año:
2012
Tipo del documento:
Article