11-Oxoaerothionin isolated from the marine sponge Aplysina fistularis shows anti-inflammatory activity in LPS-stimulated macrophages.
Immunopharmacol Immunotoxicol
; 34(6): 919-24, 2012 Dec.
Article
en En
| MEDLINE
| ID: mdl-22537094
ABSTRACT
Marine sponges of the order Verongida are a rich source of biologically active bromotyrosine-derived secondary metabolites. However, none of these compounds are known to display anti-inflammatory activity. In the present investigation, we report the anti-inflammatory effects of 11-oxoaerothionin isolated from the Verongida sponge Aplysina fistularis. When RAW264.7 cells and primary macrophages were preincubated with 11-oxoaerothionin and stimulated with LPS (lipopolysaccharide), a concentration-dependent inhibition of iNOS(inducible nitric oxide synthase) protein and NO(2)(-) (Nitrite) production were observed. The same effect was observed when proinflammatory cytokines and PGE(2) (Prostaglandin E2) production was evaluated. In summary, we demonstrated that in the presence of LPS, 11-oxoaerothionin suppresses NO(2) and iNOS expression as well as inflammatory cytokines and PGE(2).
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Oxazoles
/
Poríferos
/
Compuestos de Espiro
/
Macrófagos Alveolares
/
Macrófagos Peritoneales
/
Antiinflamatorios
Límite:
Animals
Idioma:
En
Año:
2012
Tipo del documento:
Article