[Survey on the transmission of HIV drug resistance in Kunming, Yunnan province in 2010].
Zhonghua Liu Xing Bing Xue Za Zhi
; 33(1): 75-7, 2012 Jan.
Article
en Zh
| MEDLINE
| ID: mdl-22575116
ABSTRACT
OBJECTIVE:
To study the HIV drug resistance (HIVDR) transmission in Kunming city of Yunnan province in 2010.METHODS:
Referring to the guidelines for HIV drug resistance threshold survey (HIVDR-TS) set by WHO, 62 plasma samples of recently reported HIV-infected individuals who were older than 25 years of age, were collected from January to August 2010. Genotyping of pol genetic mutations associated with HIVDR with reverse transcriptional PCR was performed and the prevalence of HIV-1 drug resistance transmission was evaluated.RESULTS:
Of the 62 plasma samples, 54 were successfully sequenced and genotyped on pol sequence. Based on the pol sequences, HIV subtypes including CRF08_BC (53.2%), CRF07_BC (25.5%), CRF01_AE (19.1%) and C (2.1%) were identified. According to the time of sampling, the first 47 sequenced samples were used for drug resistance prevalence analysis. A protease inhibitor (PI) relative mutation was found in one sample. Based on the WHO standard, the prevalence of transmitted HIV-1 drug resistance was < 5%.CONCLUSION:
HIV-1 drug resistant strains transmission was still catalogued as low prevalence level in Kunming. To prevent the increase of HIVDR prevalence, normative treatment and scientific management to AIDS patients seemed to be quite important.
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Banco de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
VIH-1
/
Farmacorresistencia Viral
Tipo de estudio:
Guideline
/
Qualitative_research
/
Risk_factors_studies
Límite:
Adult
/
Humans
País como asunto:
Asia
Idioma:
Zh
Año:
2012
Tipo del documento:
Article