ProBiS-2012: web server and web services for detection of structurally similar binding sites in proteins.
Nucleic Acids Res
; 40(Web Server issue): W214-21, 2012 Jul.
Article
en En
| MEDLINE
| ID: mdl-22600737
ABSTRACT
The ProBiS web server is a web server for detection of structurally similar binding sites in the PDB and for local pairwise alignment of protein structures. In this article, we present a new version of the ProBiS web server that is 10 times faster than earlier versions, due to the efficient parallelization of the ProBiS algorithm, which now allows significantly faster comparison of a protein query against the PDB and reduces the calculation time for scanning the entire PDB from hours to minutes. It also features new web services, and an improved user interface. In addition, the new web server is united with the ProBiS-Database and thus provides instant access to pre-calculated protein similarity profiles for over 29 000 non-redundant protein structures. The ProBiS web server is particularly adept at detection of secondary binding sites in proteins. It is freely available at http//probis.cmm.ki.si/old-version, and the new ProBiS web server is at http//probis.cmm.ki.si.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Conformación Proteica
/
Programas Informáticos
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Año:
2012
Tipo del documento:
Article