The effect of topiramate plasma concentration on linguistic behavior, verbal recall and working memory.
Epilepsy Behav
; 24(3): 365-72, 2012 Jul.
Article
en En
| MEDLINE
| ID: mdl-22658432
ABSTRACT
This is the first study of the effect of topiramate on linguistic behavior and verbal recall using a computational linguistics system for automated language and speech analysis to detect and quantify drug-induced changes in speech recorded during discourse-level tasks. Healthy volunteers were administered a single, 100-mg oral dose of topiramate in two double-blind, randomized, placebo-controlled, crossover studies. Subjects' topiramate plasma levels ranged from 0.23 to 2.81 µg/mL. We found a significant association between topiramate levels and impairment on measures of verbal fluency elicited during a picture description task, correct number of words recalled on a paragraph recall test, and reaction time recorded during a working memory task. Using the tools of clinical pharmacology and computational linguistics, we elucidated the relationship between the determinants of a drug's disposition as reflected in plasma concentrations and their impact on cognitive functioning as reflected in spoken language discourse.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Recuerdo Mental
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Habla
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Aprendizaje Verbal
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Fructosa
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Memoria a Corto Plazo
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2012
Tipo del documento:
Article